RESEARCH ARTICLE


Glucose and Lipid Metabolism in Spontaneously Diabetic Torii Rat



Yasuko Mera, Takeshi Ohta, Tomohiko Sasase*
Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan. Tel: +81 72 681 9700; Fax: +81 72 681 9722; E-mail: tomohiko.sasase@jt.com

Article Information


Identifiers and Pagination:

Year: 2011
Volume: 4
First Page: 55
Last Page: 59
Publisher Id: TODIAJ-4-55
DOI: 10.2174/1876524601104010055

Article History:

Received Date: 27/04/2010
Revision Received Date: 30/10/2010
Acceptance Date: 15/01/2011
Electronic publication date: 28/3/2011
Collection year: 2011

© Mera et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Japan Tobacco Inc., Central Pharmaceutical Research Institute, Biological/Pharmacological Research Laboratories, 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan.


Abstract

The impairment of glucose metabolism may lead to type 2 diabetes and the malfunction of lipid metabolism contributing to metabolic syndrome, which increases risk of heart disease, vascular disease, and type 2 diabetes. Our previous study provided evidence for involvement of hepatic glucose metabolic disorder in onset and progress of diabetes in Spontaneously Diabetic Torii (SDT) rats. As it is increasingly important to elucidate the mechanism of onset of diabetes and to develop drugs to prevent diabetic pathological progress, SDT rat should offer a highly useful model of spontaneous diabetic onset for such studies. In addition, abnormality in triglyceride (TG) absorption and impaired lipid catabolism antecedent to hypoinsulinemia/hyperglycemia seem to cause postprandial hypertriglyceridemia in SDT rat; hence, the characteristics of lipid metabolism in SDT rat can be useful in studies of diabetic hypertriglyceridemia and TG metabolism.