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Objective: We aimed to investigate whether rRNA 28S/18S levels decrease with aging in Down Syndrome
(DS) individuals and whether these decreased levels are tissue-specific.
Methods: We investigated mature rRNA 28S/18S levels by Northern Blotting in blood cells from 21 younger and 21 older
DS individuals in comparison to 42 age-sex-matched controls. We also investigated these levels in oral mucosa and in
blood cells from the same DS individuals.
Results: All DS subjects showed no clinical signs of dementia at the time of the study. We did not detect differences in
rRNA 28S/18S levels among DS and control groups concerning either aging process or cell types.
Conclusions: Aging process in DS individuals was not characterized by reduced rDNA transcriptional activity and did not
indicate a preclinical marker of AD in older DS subjects.