RESEARCH ARTICLE


Prevalence of Diabetes Mellitus and its Associated Risk Indicators in a Rural Bangladeshi Population



Afroza Akhter1, *, Kaniz Fatema1, Afsana Afroz1, Bishwajit Bhowmik2, Liaquat Ali3, Akhtar Hussain2
1 Department of Epidemiology & Biostatistics, Bangladesh Institute of Health Sciences (BIHS), 125/1 Darus Salam, Mirpur, Dhaka-1216, Bangladesh.
2 Department of International Health, University of Oslo, PO Box - 1130, Blindern, 0318 Oslo, Norway
3 Deptartmen of Biochemistry & Cell Biology, BIHS, 125/1 Darus Salam, Mirpur, Dhaka-1216, Bangladesh.

Article Information


Identifiers and Pagination:

Year: 2011
Volume: 4
First Page: 6
Last Page: 13
Publisher Id: TODIAJ-4-6
DOI: 10.2174/1876524601104010006

Article History:

Received Date: 28/10/2010
Revision Received Date: 09/01/2011
Acceptance Date: 25/01/2011
Electronic publication date: 29/3/2011
Collection year: 2011

© Akhter et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of International Health, Faculty of Medicine, University of Oslo, Fredrik Holsts House, Ullevål Terrace, PO Box - 1130, Blindern, 0318 Oslo, Norway. E-mail: akhtar.hussain@medisin.uio.no


Abstract

Objective: We aimed to investigate whether rRNA 28S/18S levels decrease with aging in Down Syndrome (DS) individuals and whether these decreased levels are tissue-specific. Methods: We investigated mature rRNA 28S/18S levels by Northern Blotting in blood cells from 21 younger and 21 older DS individuals in comparison to 42 age-sex-matched controls. We also investigated these levels in oral mucosa and in blood cells from the same DS individuals. Results: All DS subjects showed no clinical signs of dementia at the time of the study. We did not detect differences in rRNA 28S/18S levels among DS and control groups concerning either aging process or cell types. Conclusions: Aging process in DS individuals was not characterized by reduced rDNA transcriptional activity and did not indicate a preclinical marker of AD in older DS subjects.

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