1 Department of Medicine, University of Toledo College of Medicine, Toledo, OH, USA
2 Clinical Professor, University of Toledo College of Medicine, Toledo, OH, USA
3 Clinical Assistant Professor, Ohio University College of Osteopathic Medicine, Toledo, OH, USA
Herpes Simplex Virus (HSV) is a double-stranded virus that affects the skin and mucous membranes. There has been a long-standing dogma stating that the virus remains dormant and is reactivated from the dorsal root ganglia. However, more recent studies have established that there is a secondary mode of viral reactivation from the epidermis itself. These two distinct reactivation patterns help explain why prophylactic antivirals do not consistently prevent herpes outbreaks.
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