RESEARCH ARTICLE
The Expression of Histamine Receptors in Skin Lesions of MRL/MPlpr/ lpr Mice
Takashi Yoshimasu*, Nobuo Kanazawa, Naoya Mikita, Fukumi Furukawa
Article Information
Identifiers and Pagination:
Year: 2008Volume: 2
First Page: 83
Last Page: 86
Publisher ID: TODJ-2-83
DOI: 10.2174/1874372200802010083
Article History:
Received Date: 10/06/2008Revision Received Date: 18/06/2008
Acceptance Date: 25/06/2008
Electronic publication date: 11/7/2008
Collection year: 2008
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Systemic lupus erythematosus (SLE) is a chronic inflammatory disease accompanied with systemic organs disorder including skin changes. The MRL/MP-lpr/lpr (MRL/l) mouse is a model of human LE. MRL/l mice skin lesions exhibit a decreased activity in histamine-N-methyltransferase (HMT) and impaired histamine metabolism. In order to clarify the role of histamine receptors (HRs) including H1R, H2R and H3R in MRL/l skin lesions, the relationship between HRs and skin lesions was assessed by immunohistochemical staining and RT-PCR methods. The expression of H2R was seen in the non-lesional skin of 2-month-old (mo) MRL/l mice; H2R expression continued for a couple of months, and then decreased in the skin lesions of 5-mo MRL/l mice. In MRL/l skin lesions, a dense mast cell infiltration expressed H2R was seen. In conclusion, an increased expression of H2R in mast cells may be associated with histamine metabolism in skin lesions from MRL/l mice.
