RESEARCH ARTICLE


Development of an Ultraviolet A1 Light Emitting Diode-based Device for Phototherapy



Shunko A. Inada*, 1, 3, Satoshi Kamiyama1, Isamu Akasaki1, Kan Torii3, Takuya Furuhashi3, Hiroshi Amano2, Akimichi Morita3
1 Department of Materials Science and Engineering, Faculty of Science and Technology, Meijo University, 1-501 Shiogamaguchi Tempaku-ku, Nagoya 468-8502, Japan
2 Graduate School of Engineering, Akasaki Research Center, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464- 8603, Japan
3 Department of Geriatric and Environmental Dermatology, Nagoya City University Graduate School of Medical Sciences, Nagoya 467-8601, Japan

Article Information


Identifiers and Pagination:

Year: 2012
Volume: 6
First Page: 13
Last Page: 24
Publisher ID: TODJ-6-13
DOI: 10.2174/1874372201206010013

Article History:

Received Date: 13/01/2012
Revision Received Date: 14/02/2012
Acceptance Date: 18/02/2012
Electronic publication date: 20/3/2012
Collection year: 2012

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Creative Commons License
© 2012 Inada et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Materials Science and Engineering, Faculty of Science and Technology, Meijo University, 1- 501 Shiogamaguchi Tempaku-ku, Nagoya 468-8502, Japan; Tel: +81-052-832-1151; Fax: +81-052-832-1244; E-mail: m0641503@ccalumni.meijo-u.ac.jp


Abstract

We developed a novel phototherapy device based on an ultraviolet light emitting diode (UV LED) with a peak wavelength of 365 nm and the full width at half maximum of 10 nm. The equipment comprised a 16 x 16 (50 cm x 50 cm) UV LED matrix. The system was designed to irradiate only the diseased part of the skin. To evaluate the characteristics of this device, we compared consumed power, irradiation intensity, uniformity of the irradiation intensity, rise time and stability of the irradiation intensity, and in vivo irradiation of mice between a conventional UVA1 (340-400 nm) phototherapy device and the UV LED device. The UVA1 LED device exhibited more desirable characteristics than the UVA1 lamp device, i.e., fewer thermal effects on in vitro and in vivo systems. Furthermore, to evaluate the efficacy of both light sources, cultured T cells were irradiated and the induction of apoptosis was analyzed. Both light sources efficiently induced apoptosis.

Keywords: Apoptosis, phototherapy, ultraviolet light emitting diode (UV LED).