RESEARCH ARTICLE


CEA (Carcinoembryonic Antigen) and CEACAM6 (CEA-Related Cell Adhesion Molecul 6) are Expressed in Psoriasis Vulgaris



Akihiko Fujisawa1, Kiyofumi Egawa2, 3, Yumi Honda4, Masahide Kuroki5, Masatoshi Jinnin1, Hironobu Ihn*, 1
1 Department of Dermatology and Plastic Surgery, Faculty of Life Sciences, Kumamoto University, Japan
2 Department of Dermatology, The Jikei University School of Medicine, Tokyo, Japan
3 Department of Microbiology, Kitasato University School of Allied Health Science, Sagamihara, Japan
4 Department of Surgical Pathology, Kumamoto University Hospital, Kumamoto, Japan
5 Department of Biochemistry, Faculty of Medicine, Fukuoka University, Fukuoka, Japan

Article Information


Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 47
Last Page: 52
Publisher ID: TODJ-7-47
DOI: 10.2174/1874372220130822005

Article History:

Received Date: 13/08/2013
Revision Received Date: 17/08/2013
Acceptance Date: 17/08/2013
Electronic publication date: 18/10/2013
Collection year: 2013

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Creative Commons License
© Fujisawa et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the 1-1-1 Honjo, Kumamoto 860-8556, Kumamoto, Japan; Tel: +81-96-373-5233; Fax: +81-96-373-5235; E-mail: ihn-der@kumamoto-u.ac.jp


Abstract

Carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) belong to a group of mammalian immunoglobulin-related glycoproteins. The CEACAM family of proteins has been implicated in intracellular-signalingmediated effects that govern the growth and differentiation of normal and cancer cells.

In this study, the expression of CEACAMs was studied immunohistochemically in the skin of patients with psoriasis, using a panel of polyclonal (PoAb) and monoclonal (F34-187, F33-104, and F106-88) antibodies that recognize different epitopes of CEA and related molecules (CEACAMs), in comparison with the expression of cell differentiation and proliferation markers, such as involucrin, PCNA, Ki-67 and CK16. The expression of these molecules in adjacent parts without eruptions was also investigated for comparison.

The three CEACAMs, CEACAM1, CEA and CEACAM6, were expressed, limited to the upper part of the proliferated epidermal cells which expressed involucrin in the psoriatic lesions. Only the upper epidermal cell layers of the psoriatic lesions expressed these markers more highly than the adjacent normal skin. These results suggested that the expression of CEACAMs is related to epidermal cell de-differentiation in the diseased skin of psoriasis vulgaris.

Keywords: Psoriasis, CEA, CEACAM5.