The Open Infectious Diseases Journal




ISSN: 1874-2793 ― Volume 10, 2018
RESEARCH ARTICLE

Exploring the Impact of Climate Variability on Malaria Transmission Using a Dynamic Mosquito-Human Malaria Model



Gbenga J. Abiodun1, 2, *, Peter J. Witbooi2, Kazeem O. Okosun3, Rajendra Maharaj4
1 Research Unit, Foundation for Professional Development, Pretoria 0184, Republic of South Africa
2 Department of Mathematics and Applied Mathematics, University of the Western Cape, Private Bag X17, Bellville7535, Republic of South Africa
3 Department of Mathematics, Vaal University of Technology, X021, Vanderbijlpark, 1900, Republic of South Africa
4 Office of Malaria Research, South African Medical Research Council, Durban, Republic of South Africa

Abstract

Introduction:

The reasons for malaria resurgence mostly in Africa are yet to be well understood. Although the causes are often linked to regional climate change, it is important to understand the impact of climate variability on the dynamics of the disease. However, this is almost impossible without adequate long-term malaria data over the study areas.

Methods:

In this study, we develop a climate-based mosquito-human malaria model to study malaria dynamics in the human population over KwaZulu-Natal, one of the epidemic provinces in South Africa, from 1970-2005. We compare the model output with available observed monthly malaria cases over the province from September 1999 to December 2003. We further use the model outputs to explore the relationship between the climate variables (rainfall and temperature) and malaria incidence over the province using principal component analysis, wavelet power spectrum and wavelet coherence analysis. The model produces a reasonable fit with the observed data and in particular, it captures all the spikes in malaria prevalence.

Results:

Our results highlight the importance of climate factors on malaria transmission and show the seasonality of malaria epidemics over the province. Results from the principal component analyses further suggest that, there are two principal factors associated with climates variables and the model outputs. One of the factors indicate high loadings on Susceptible, Exposed and Infected human, while the other is more correlated with Susceptible and Recovered humans. However, both factors reveal the inverse correlation between Susceptible-Infected and Susceptible-Recovered humans respectively. Through the spectrum analysis, we notice a strong annual cycle of malaria incidence over the province and ascertain a dominant of one year periodicity. Consequently, our findings indicate that an average of 0 to 120-day lag is generally noted over the study period, but the 120-day lag is more associated with temperature than rainfall. This is consistence with other results obtained from our analyses that malaria transmission is more tightly coupled with temperature than with rainfall in KwaZulu-Natal province.

Keywords: Climate variability, Mathematical model, Anopheles arabiensis, Malaria incidence, South Africa, Malaria dynamics.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 10
First Page: 88
Last Page: 100
Publisher Id: TOIDJ-10-88
DOI: 10.2174/1874279301810010088

Article History:

Received Date: 17/4/2018
Revision Received Date: 6/6/2018
Acceptance Date: 12/6/2018
Electronic publication date: 24/7/2018
Collection year: 2018

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© 2018 Abiodun et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Research Unit, Foundation for Professional Development, Pretoria 0184, South Africa; Tel: +27 21 959 6906; E-mail: 3109433@myuwc.ac.za


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