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The susceptibility of coryneform bacteria has been studied mostly in invasive pathogens, less data
are available concerning the mucosal or physiological fluid strains. At the same time they can serve as the source of various
infections, besides the invasive infections also the local ones, for example, coryneforms of male genital tract have
been associated with inflammatory prostatitis.
Material and Methods:
A total of 62 coryneform isolates from human semen were tested for susceptibility to eight antimicrobial
agents using the E test method.
All strains were susceptible to ampicillin-sulbactam and only a few were resistant to penicillin G and TMP/SMX
while nearly one third of strains were resistant or intermediate to doxycycline (35%) and norfloxacin (29%), and more
than half to clindamycin (63%), nitrofurantoin (62%) and erythromycin (53%). The strains showing resistance to at least 3
antimicrobials belonged to Corynebacterium group F1, Corynebacterium seminale and Cellulomonas/Microbacterium sp.
A distinct co-occurring macrolide and lincosamine resistance pattern was common.
Ampicillin-sulbactam, penicillin G and TMP/SMX revealed the highest activity against coryneforms isolated
from semen that were frequently resistant or intermediate to several other antimicrobials. Norfloxacin revealed only moderate
activity against prostatitis-associated Corynebacterium group G.