RESEARCH ARTICLE


Antimicrobial Susceptibility Patterns of Coryneform Bacteria Isolated from Semen



Silver Türk1, Margus Punab2, Reet Mändar*, 1
1 Department of Microbiology, University of Tartu, Ravila 19, 50411 Tartu, Estonia
2 Andrology Centre, Tartu University Hospital, Puusepa 1a, 50406 Tartu, Estonia

Article Information


Identifiers and Pagination:

Year: 2009
Volume: 3
First Page: 31
Last Page: 36
Publisher Id: TOIDJ-3-31
DOI: 10.2174/1874279300903010031

Article History:

Received Date: 15/12/2008
Revision Received Date: 12/01/2009
Acceptance Date: 13/01/2009
Electronic publication date: 24/2/2009
Collection year: 2009

© 2009 Türk et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Microbiology, University of Tartu, Ravila 19, 50411 Tartu, Estonia; Tel: +372 7 374 178; Fax: +372 7 374 172; E-mail: Reet.Mandar@ut.ee


Abstract

Background:

The susceptibility of coryneform bacteria has been studied mostly in invasive pathogens, less data are available concerning the mucosal or physiological fluid strains. At the same time they can serve as the source of various infections, besides the invasive infections also the local ones, for example, coryneforms of male genital tract have been associated with inflammatory prostatitis.

Material and Methods:

A total of 62 coryneform isolates from human semen were tested for susceptibility to eight antimicrobial agents using the E test method.

Results:

All strains were susceptible to ampicillin-sulbactam and only a few were resistant to penicillin G and TMP/SMX while nearly one third of strains were resistant or intermediate to doxycycline (35%) and norfloxacin (29%), and more than half to clindamycin (63%), nitrofurantoin (62%) and erythromycin (53%). The strains showing resistance to at least 3 antimicrobials belonged to Corynebacterium group F1, Corynebacterium seminale and Cellulomonas/Microbacterium sp. A distinct co-occurring macrolide and lincosamine resistance pattern was common.

Conclusion:

Ampicillin-sulbactam, penicillin G and TMP/SMX revealed the highest activity against coryneforms isolated from semen that were frequently resistant or intermediate to several other antimicrobials. Norfloxacin revealed only moderate activity against prostatitis-associated Corynebacterium group G.

Keywords: Antimicrobial susceptibility, Corynebacterium, coryneform.