RESEARCH ARTICLE
Correct Species Identification of Streptococcus Using Multi Locus Sequence Analysis for Disproving Relapse of Two Episodes of Infective Endocarditis
Stine Odgaard Poulsen1, Louise Rasmussen2, Xiaohui C. Nielsen2, Ulrik S. Justesen3, Jens J. Christensen2, Sabine Gill1
Article Information
Identifiers and Pagination:
Year: 2015Volume: 9
First Page: 35
Last Page: 38
Publisher Id: TOIDJ-9-35
DOI: 10.2174/1874279301509010035
Article History:
Received Date: 24/1/2014Revision Received Date: 30/3/2015
Acceptance Date: 13/4/2015
Electronic publication date: 30/7/2015
Collection year: 2015
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
When repetitive infective endocarditis episodes occur in the same patient, accurate species identification is essential for differentiating relapse and a new episode. We report a case, which has had four episodes of IE within 2 years: episode 1 due to Enterococcus faecalis, episode 2 due to Mitis group Streptococcus, Episodes 3 and 4 due to Salivarius group Streptococcus. Detailed molecular examinations using Multi Locus Sequence Analysis (MLSA) convincingly documented that the two strains from episodes 3 and 4 were different. Thus, it was not a relapse, but a new infection and, importantly, not the result of antibiotic treatment failure.