As growing numbers of older adults can expect lives characterized by longevity, the scientific community is challenged to understand those factors that can contribute to maintenance of good health and quality of life for the old-old. Prior research has focused on the importance of genetic factors, social inequalities and health care related influences on quality of life in old age.However, the role of proactive adaptations by older adults to enhance their own quality of life has only recently gained recognition. This special Hot Topics Issue of Open Longevity Science brings attention to this emerging trend. We do so by showcasing contributions by scientists from different disciplines using different theoretical lenses and research approaches to understand both self empowerment and services that can facilitate empowerment of the aged to take action on their own behalf.