The Open Medicinal Chemistry Journal

ISSN: 1874-1045 ― Volume 12, 2018

Effects on Sperms’ Quality of Selegiline in Aged Rats

Huba Kalász1, *, Julianna Thuróczy2, Gellért Karvaly3, Lajos Balogh4, István Gyertyán1, Edit Tóth-Molnár5, Ernest Adeghate6, Kornélia Tekes7
1 Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary
2 Animal Health Center Budafok, H-1221 Budapest, Kossuth Lajos Str. 52. Hungary
3 Department of Laboratory Medicine, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary
4 National “FJC” Research Institute for Radiobiology and Radiohigiene, H-1221 Budapest, Anna Str. 5. Hungary
5 Department of Ophthalmology, University of Szeged, 6720 Szeged, Korányi fasor 10- 11, Hungary
6 Department of Anatomy, United Arab Emirates University, P.O.Box 17666, Al Ain, United Arab Emirates
7 Department of Pharmacodynamics, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary



Selegiline is used to treat Parkinsonian patients. Other indications of its use have recently been discovered.


Scouting special and beneficial side effects of selegiline treatment.


Two-year old male Wistar rats were daily treated with 0.25 mg/kg of selegiline s.c. (subcutaneous injection). The rats were sacrificed following a four-weeks’ treatment.


Mass of testes, number of sperms, progressive motility of sperms, and their viability definitely increased.


Selegiline can successfully be used to stop/counterbalance certain symptoms of aging.

Keywords: Selegiline, Aged-rats, Semen, Dopamine, Testis, Sperm, Testosterone, Cortisol.

Article Information

Identifiers and Pagination:

Year: 2017
Volume: 11
First Page: 138
Last Page: 145
Publisher Id: TOMCJ-11-138
DOI: 10.2174/1874104501711010138

Article History:

Received Date: 14/08/2017
Revision Received Date: 2/11/2017
Acceptance Date: 13/11/2017
Electronic publication date: 30/11/2017
Collection year: 2017

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© 2017 Kalász et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4. 0 International Public License (CC-BY 4. 0), a copy of which is available at: https://creativecommons. org/licenses/by/4. 0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Pharmacology and Pharmacotherapy, Semmelweis University, 1089 Budapest, Nagyvárad tér 4, Hungary; Tel: +36309316218; E-mail:


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