Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary
Tolperisone (2-methyl-1-(4-methylphenyl)-3-piperidin-1-ylpropan-1-one hydro-chloride) was introduced in the
clinical practice more than forty years ago and is still evaluated as a widely applicable compound in pathologically elevated
skeletal muscle tone (spasticity) and related pains of different origin. In the present review, basic pharmacodynamic
effects measured on whole animals, analyses of its actions on cell and tissue preparations and molecular mechanism of action
on sodium and calcium channels are summarized as recently significantly new data were reported.
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