RESEARCH ARTICLE
Whole Genome Sequencing of Klebsiella pneumoniae Strain Unravels a New Model for the Development of Extensive Drug Resistance in Enterobacteriaceae
Mubarak Alfaresi*
Article Information
Identifiers and Pagination:
Year: 2018Volume: 12
First Page: 195
Last Page: 199
Publisher ID: TOMICROJ-12-195
DOI: 10.2174/1874285801812010195
Article History:
Received Date: 15/03/2018Revision Received Date: 05/06/2018
Acceptance Date: 06/06/2018
Electronic publication date: 29/06/2018
Collection year: 2018
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Abstract
Introduction:
Increased incidence of carbapenem-resistant Enterobacteriaceae (CRE) has been reported worldwide. The WHO warns about the imminent risk to global health if the spread of resistant bacteria is not contained.
Materials and Methods:
Here, single molecule real time sequencing was used to analyse the whole genome and resistome of SKGH01, a strain of Klebsiella pneumoniae.
Results and Discussions:
The data showed that SKGH01 was resistant to all commercially available antibiotics. A complete account of extensively drug-resistant (XDR) CRE at a genomic level and the entire location map of all antibiotic resistance components are here presented. Additionally, this work proposes a model of XDR acquisition in Enterobacteriaceae.