The Open Microbiology Journal

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Antimicrobial Resistance Profiling of Coagulase-Negative Staphylococci in a Referral Center in South Italy: A Surveillance Study

Daria Nicolosi1, Diana Cinà2, Concettina Di Naso2, Floriana D’Angeli3, Mario Salmeri1, Carlo Genovese1, *
1 Department of Biomedical and Biotechnological Sciences, Microbiology Section, University of Catania, Catania, Italy
2 Clinical Pathology, Garibaldi Hospital, Catania, Italy
3 Department of Biomedical and Biotechnological Sciences, Biochemistry section, University of Catania, Catania, Italy



CoNS are part of the normal flora of the skin, upper respiratory tract and human intestine. CoNS are able to colonize host tissues or inert materials such as prosthetics, heart valves, pacemakers, and urinary and venous catheters. They can also internalize in host cells, thus eluding immune defenses and attack by antibiotics.


In this study, we collected the epidemiological data and determined the antibiotic susceptibility of 828 CoNS, collected in Garibaldi Hospital (Catania, Italy) between January 2016 and October 2018.


Strains were evaluated by determining the Minimum Inhibitory Concentration (MIC) using the broth microdilution method, according to the guidelines of the Clinical and Laboratory Standards Institute. The antibiotic sensitivity pattern of CoNS against eighteen antibiotics was determined.


For all the 828 clinical isolates, varying resistance rates were observed: ampicillin (87%), penicillin (86%), amoxicillin-clavulanate (71%), oxacillin (70%), erythromycin (69%), azithromycin (68%), levofloxacin (55%), ciprofloxacin (54%), gentamycin (47%), moxifloxacin (42%), trimethoprim-sulfamethoxazole (30%), clindamycin (28%), tetracycline (24%), rifampicin (20%), quinupristin-dalfopristin (synercid) (4%). No strains investigated demonstrated resistance to teicoplanin, vancomycin and linezolid.


Our results highlight the importance of monitoring the evolution of CoNS resistance in order to implement control measures and reduce the risk of spread in the population.

Keywords: Coagulase-negative staphylococci, Nosocomial pathogens, Epidemiological data, Antimicrobial, Resistance, Virulence factors.

Article Information

Identifiers and Pagination:

Year: 2020
Volume: 14
First Page: 91
Last Page: 97
Publisher Id: TOMICROJ-14-91
DOI: 10.2174/1874285802014010091

Article History:

Received Date: 28/01/2019
Revision Received Date: 09/04/2020
Acceptance Date: 10/04/2020
Electronic publication date: 21/05/2020
Collection year: 2020

© 2020 Nicolosi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Biomedical and Biotechnological Sciences, Microbiology Section, University of Catania, Via Santa Sofia, 97, Catania, 95123, Italy; Tel: +39 095 4781252; E-mail:

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