The Open Magnetic Resonance Journal
(Discontinued)
ISSN: 1874-7698 ― Volume 3, 2010
Optimum Voxel Volume for Maximizing Contrast-to-Noise Ratio in BOLD Functional MRI
The Open Magnetic Resonance Journal, 2008, 1: 54-59
Norihiko Fujita, Kouji Okada, Hisashi Tanaka , Kenya Murase
Department of Radiology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Electronic publication date 27/5/2008
[DOI: 10.2174/1874769800801010054]
Abstract:
Recent studies suggest that physiological noise, which determines the SNR of the fMRI time course at commonly used spatial resolutions, is largely spatially coherent. It is theoretically shown that the ratio of such a spatially coherent physiological to thermal noise determines the optimum voxel volume for maximizing BOLD CNR, relatively independent of the size of activation.
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