The Open Neuroimaging Journal

ISSN: 1874-4400 ― Volume 13, 2019

Contrast Mechanisms for Tumor Cells by High-frequency Ultrasound

Yada Juntarapaso1, Chiaki Miyasaka2, Richard L. Tutwiler1, Pavlos Anastasiadis3, 4, *
1 Department of Acoustics, The Pennsylvania State University, University Park, PA, USA
2 Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, USA
3 Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA
4 Marlene and Stewart Greenebaum Comprehensive Cancer Center, University of Maryland, School of Medicine, Baltimore, MD, USA


Scanning Acoustic Microscopy (SAM) is a powerful technique for both the non-destructive determination of mechanical and elastic properties of biological specimens and for the ultrasonic imaging at a micrometer resolution. The implication of biomechanical properties during the onset and progression of disease has been established rendering a profound understanding of the relationship between mechanoelastic and biochemical signaling at a molecular level crucial. Computer simulation algorithms were developed for the generation of images and the investigation of contrast mechanisms in high-frequency and ultra-high frequency SAM. Furthermore, we determined the mechanical and elastic properties of HeLa and MCF-7 cells. Algorithms for simulating V(z) responses were developed based on the ray and wave theory (angular spectrum). Theoretical simulations for high-frequency SAM array designs were performed with the Field II software. In these simulations, we applied phased array beam formation and dynamic apodization and focusing. The purpose of our transducer simulations was to explore volumetric imaging capabilities. The novel transducer arrays designed in this research aim at improving the performance of SAM systems by introducing electronic steering and hence, allowing for the 4D imaging of cells and tissues.

Keywords: High-frequency ultrasound, Focused ultrasound, Scanning acoustic microscopy, Phased arrays, Dynamic apodization, Cancer metastasis, Tumor microenvironment, Biomechanical properties.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
Issue: Suppl 1: M4
First Page: 105
Last Page: 119
Publisher Id: TONIJ-12-105
DOI: 10.2174/1874440001812010105

Article History:

Received Date: 12/3/2018
Revision Received Date: 20/5/2018
Acceptance Date: 28/5/2018
Collection year: 31/12/2018

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© 2018 Juntarapaso et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this authors at the Department of Diagnostic Radiology and Nuclear Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA; Tel: +1 (410) 706-4499; E-mails:,


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