The Open Neuroimaging Journal

ISSN: 1874-4400 ― Volume 13, 2019

Functional MRI of Rehabilitation in Chronic Stroke Patients Using Novel MR-Compatible Hand Robots

Dionyssios Mintzopoulos1, 2, Azadeh Khanicheh3, Angelos A Konstas1, 2, Loukas G Astrakas1, 2, Aneesh B Singhal2, 4, Michael A Moskowitz2, 5, Bruce R Rosen2, A. Aria Tzika*, 1, 2
1 NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner’s Burn Institute, Harvard Medical School, Boston, MA 02114, USA
2 Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
3 Department of Mechanical and Industrial Engineering, Northeastern University, Boston, MA 02115, USA
4 Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA 02114, USA
5 Neuroscience Center, Departments of Neurology and Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA


We monitored brain activation after chronic stroke by combining functional magnetic resonance imaging (fMRI) with a novel MR-compatible, hand-induced, robotic device (MR_CHIROD). We evaluated 60 fMRI datasets on a 3 T MR system from five right-handed patients with left-sided stroke ≥6 months prior and mild to moderate hemiparesis. Patients trained the paretic right hand at approximately 75% of maximum strength with an exercise ball for 1 hour/day, 3 days/week for 4 weeks. Multi-level fMRI data were acquired before, during training, upon completion of training, and after a non-training period using parallel imaging employing GeneRalized Autocalibrating Partially Parallel Acquisitions (GRAPPA) while the participant used the MR_CHIROD. Training increased the number of activated sensorimotor cortical voxels, indicating functional cortical plasticity in chronic stroke patients. The effect persisted four weeks after training completion, indicating the potential of rehabilitation in inducing cortical plasticity in chronic stroke patients.

Keywords: Functional Magnetic Resonance Imaging (fMRI), brain, stroke, rehabilitation.

Article Information

Identifiers and Pagination:

Year: 2008
Volume: 2
First Page: 94
Last Page: 101
Publisher Id: TONIJ-2-94
DOI: 10.2174/1874440000802010094
PMID: 19526075
PMCID: PMC2695624

Article History:

Received Date: 11/12/2007
Revision Received Date: 05/5/2008
Acceptance Date: 11/7/2008
Electronic publication date: 27/9/2008
Collection year: 2008

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© Mintzopoulos et al; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License ( which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

* Address correspondence to this author at the NMR Surgical Laboratory, Department of Surgery, Massachusetts General Hospital and Shriner’s Burn Institute, Harvard Medical School, Boston, MA 02114, USA; E-mail:


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