The Open Neuroimaging Journal




ISSN: 1874-4400 ― Volume 13, 2019

Dysfunctional Cortical Connectivity During the Auditory Oddball Task in Patients with Schizophrenia



Toshiro Fujimoto a, *, Eiichi Okumura b, Kouzou Takeuchi a, Atsushi Kodabashi a, Toshiaki Otsubo a, Katsumi Nakamura a, Shinichiro Kamiya a, Yuji Higashi a, Tadahiko Yuji a, Kenichi Honda a, Susumu Shimooki a, Toshiyo Tamura c
a Fujimoto Hayasuzu Hospital, Yokakai Association, Miyazaki, Japan
b Department of MEG, Yokogawa Electric Corporation, Ishikawa, Japan
c Osaka electro-communication University, Faculty of Biomedical Engineering, Osaka, Japan

Abstract

Background:

We studied the imaginary coherence (IC) of gamma frequency oscillations between brain regions of male schizophrenia patients during an auditory oddball task using magnetoencephalography (MEG) and electroencephalography (EEG).

Methods:

Subjects were 10 right-handed male schizophrenia patients, evaluated by the positive and negative symptom scale (PANSS), and 10 healthy controls. Functional connectivity during the auditory oddball task was reconstructed in low (30-50 Hz) and high (50-100 Hz) gamma bands, and represented by imaginary coherence (IC) based on significant oscillatory power changes. We calculated correlations between PANSS scores and IC.

Results:

In the high gamma band, IC between left occipital and right prefrontal lobe areas during the time window 750-1000 ms from stimulus onset showed negative correlations with total negative scores, total positive scores, the sum of positive and negative scores in PANSS, conceptual disorganization, and social avoidance scores. In the low gamma band, IC between the same areas from 250-500 ms also showed a negative correlation with the conceptual disorganization score. In the same time window, IC between left occipital and right frontoparietal lobe areas in the low gamma band showed a positive correlation with hallucinatory behavior; IC between right temporal pole and left prefrontal lobe areas showed a positive correlation with delusion scores, although these ICs were decreased relative to controls.

Conclusions:

Functional disconnection of high and low gamma bands in auditory oddball task may play an important role in the auditory processing in schizophrenia patients.

Keywords: Magnetoencephalography, gamma band, functional connectivity, PANSS, schizophrenia, P300.


Article Information


Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 15
Last Page: 26
Publisher Id: TONIJ-7-15
DOI: 10.2174/1874440001307010015
PMID: 23750187
PMCID: PMC3636485

Article History:

Received Date: 17/10/2012
Revision Received Date: 16/1/2013
Acceptance Date: 16/1/2013
Electronic publication date: 5/4/2013
Collection year: 2013

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© Fujimoto et al; Licensee Bentham Open

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.


* Address correspondence to this author at the 17-4 Hayasuzu-cho, Miyakonojo, Miyazaki 885-0055, Japan; Tel: +81-986-22-4111; Fax: +81-986-24-5129; E-mail: ceo@fujimoto.or.jp


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