Bilateral Choroidal Metastases from Endobronchial Carcinoid Treated with Somatostatin Analogues
Deborah De Bruyn1, *, Jan Lamont2, Erik Vanderstraeten3, Simon Van Belle4, Elise Platteau1, 5, Julie De Zaeytijd1, Kristien P. Hoornaert1, 5
1 Department Ophthalmology, Ghent University Hospital and Ghent University, Ghent, Belgium
2 Department Pneumology, Maria Middelares Hospital, Ghent, Belgium
3 Department Gastroenterology, Maria Middelares Hospital, Ghent, Belgium
4 Department Medical Oncology, Ghent University Hospital and Ghent University, Ghent, Belgium
5 Department Ophthalmology, Maria Middelares Hospital, Ghent, Belgium
To describe a patient with bilateral multifocal choroidal metastases from an endobronchial carcinoid treated with a somatostatin analogue.
A 60-year-old woman presenting with photopsia in the left eye underwent an extensive ophthalmic examination, including fluorescein angiography, OCT and ultrasound.
Fundoscopy revealed a small retinal tear in the left eye, for which she received laser treatment. In addition, choroidal masses were detected in both eyes. Her medical history of a pneumectomy for a bronchial carcinoid six years earlier together with recent elevated chromogranin A blood levels prompted a diagnosis of choroidal metastases. Subsequently, a Gallium-68 DOTANOC positron emitting tomography/computer tomography scan revealed a spinal cord metastasis and mediastinal as well as mesenterial lymph node invasion. Systemic treatment with Sandostatin®, a somatostatin analogue was started. Up until two years after the initial presentation and treatment, these choroidal lesions remained stable without any signs of growth.
Endobronchial carcinoid tumors have an indolent nature and long-term follow-up is recommended for early detection of metastases. Although treatment with somatostatin analogues rarely induces complete tumor regression, tumor stabilization and prevention of symptoms related to hormone secretion is achieved. This well-tolerated systemic treatment provides a worthy alternative treatment for choroidal metastasis compared to classic radiotherapy without any risk of radiation or laser-related visual loss.
Keywords: Carcinoid tumor, Choroidal metastases, Chromogranine A, Somatostatin analogues.
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