The Open Ophthalmology Journal




ISSN: 1874-3641 ― Volume 13, 2019
RESEARCH ARTICLE

Efficacy and Safety of Switching from Tafluprost to a Tafluprost/Timolol Fixed Combination in Patients With Primary Open-Angle Glaucoma



Kenji Inoue1, *, Takeaki Ueda1, Kyoko Ishida2, Goji Tomita2
1 Inouye Eye Hospital, Tokyo, Japan
2 Department of Ophthalmology, Toho University Ohashi Medical Center, Tokyo, Japan

Abstract

Background:

The Tafluprost/Timolol Fixed Combination (TTFC) has demonstrated efficacy and safety in reducing Intraocular Pressure (IOP). However, direct comparisons of switching from tafluprost to TTFC are limited.

Objective:

To investigate the efficacy and safety of switching from tafluprost to TTFC in patients with Primary Open-Angle Glaucoma (POAG).

Methods:

Thirty-four eyes (34 patients) with POAG that did not achieve adequate IOP reduction on tafluprost were switched to TTFC with no washout period. IOP, systolic/diastolic blood pressure and pulse rate were measured 1 and 3 months later and compared with baseline values. All participants were asked about specific adverse reactions after 1 and 3 months of treatment. Patients also completed a questionnaire about preference and adherence after 1 month of treatment.

Results:

Mean IOP after 1 and 3 months was significantly lower than at baseline (14.2 ± 2.1 mmHg and 14.1 ± 2.3 mmHg, respectively, vs 16.0 ± 2.0 mmHg, P < 0.0001). Systolic/diastolic blood pressure and pulse rate were not significantly different from baseline after 1 and 3 months. The questionnaire indicated that the frequency of missing a dose was not different before (27.3%) or after (18.2%) switching to TTFC (P = 0.2371). There were five reports of adverse reactions (14.7%), including a corneal epithelium disorder, ocular irritation, skin irritation at the wrist, and chest pain. Two patients (5.9%) withdrew because of adverse reactions.

Conclusion:

Switching from tafluprost to TTFC achieved IOP control safely and was well accepted by patients.

Keywords: Tafluprost, Tafluprost/timolol fixed combination, Primary open-angle glaucoma, Intraocular pressure, Safety, Efficacy.


Article Information


Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 121
Last Page: 126
Publisher Id: TOOPHTJ-12-121
DOI: 10.2174/1874364101812010121

Article History:

Received Date: 27/12/2017
Revision Received Date: 20/4/2018
Acceptance Date: 24/5/2018
Electronic publication date: 29/6/2018
Collection year: 2018

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© 2018 Inoue et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at Inouye Eye Hospital, 4-3 Kanda-Surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan; Tel: 03-3295-0911; Fax: 03-3295-0917; E-mail: inoue-k@inouye-eye.or.jp


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