The Open Ophthalmology Journal

ISSN: 1874-3641 ― Volume 13, 2019

Clinical Characteristics, Treatment Outcomes and Predictive Factors in Optic Neuritis

Linda Hansapinyo*, Chayanee Vivattanaseth
Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand



The causes, clinical presentations and treatment outcomes of optic neuritis are distinct among different populations. Early diagnosis based on clinical presentations plays an important role in treating optic neuritis patients.


The study aimed to determine clinical characteristics, treatment outcomes and predictive factors of treatment outcomes in optic neuritis patients with and without demyelinating disease.


A retrospective descriptive study of optic neuritis patients carried out between January 2009 and December 2016 was done. Univariate analysis and multivariate logistic regression analysis were used to evaluate the predictive factors of treatment outcomes.


Among 150 patients with optic neuritis, 58 patients were diagnosed with Neuromyelitis Optica Spectrum Disease (NMOSD), 23 patients were diagnosed with Multiple Sclerosis (MS) and 69 patients were idiopathic. The age at presentation in the NMOSD group was significantly younger than the MS group and the idiopathic group. The female:male ratio was significantly lower in the idiopathic group than in the NMOSD group. The initial Best Corrected Visual Activity (BCVA) of 20/20-20/60 (p = 0.001) and the idiopathic group (p =0.030) was associated with good visual outcomes. Initial BCVA of < 20/200 (p = 0.009) and the NMOSD group (p < 0.001) was associated with poor visual outcomes.


NMOSD is a more common cause of optic neuritis than MS in Thai population. Female patients with poor initial VA, poor response to steroids treatment, and presenting recurrent attacks are highly suspicious for NMOSD. Optic neuritis without associated demyelinating disease has a better visual outcome and lower recurrence rate.

Keywords: Optic neuritis, Neuromyelitis optica spectrum disease, Multiple sclerosis, Best corrected visual activity, ONTT, Idiopathic patients.

Article Information

Identifiers and Pagination:

Year: 2018
Volume: 12
First Page: 247
Last Page: 255
Publisher Id: TOOPHTJ-12-247
DOI: 10.2174/1874364101812010247

Article History:

Received Date: 29/6/2018
Revision Received Date: 17/7/2018
Acceptance Date: 24/7/2018
Electronic publication date: 31/08/2018
Collection year: 2018

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© 2018 Hansapinyo and Vivattanaseth.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, 110 Intawarorot Road, Sriphoom, Muang, Chiang Mai, 50200, Thailand; Tel: 6653945512; Fax: 6653946121; E-mail:


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