Effect of Acute Increases in Intraocular Pressure on Corneal Pachymetry in Rabbit Eyes Treated with Timolol Maleate
Cristina Sánchez-Barahona1, Gema Bolívar2, *, Dimitrios G. Mikropoulos3, Anastasios G. Konstas3, 4, Miguel A. Teus2, 5, 6
1 Department of Ophthalmology,Hospital Universitario de Getafe, Madrid, Spain
2 Department of Ophthalmology, Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Spain
3 3rd University Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
4 1st University Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece
5 Department of Ophthalmology, Clínica Novovisión, Madrid, Spain
6 Department of Ophthalmology, Universidad de Alcalá, Alcalá de Henares, Spain
To evaluate in an in vivo rabbit model, the effect of topical timolol maleate therapy on the central corneal thickness response to acute intraocular pressure increases.
In this prospective and interventional controlled study, the central corneal thickness and intraocular pressure were measured in vivo in 12 rabbit eyes treated with topical timolol maleate for 1 month and in 12 controls at baseline, and after the intraocular pressure (measured by direct cannulation of the anterior chamber) was increased to 15 and 30 mmHg using a forced saline infusion into the anterior chamber.
There were no significant differences in the basal central corneal thickness values (control group, 373.2±12.9 µm; study group, 377.5±19.2 µm, p=0.5) or the central corneal thickness values when the intraocular pressure was increased to 15 mmHg (control group, 335.2±14.3 µm; study group, 330.0±32.1 µm, p=0.6) and to 30 mmHg (study group, 318.8±25.3 µm; control group, 329.8±21.0 µm, p=0.3).
Rabbit corneas treated with topical timolol maleate for 1 month did not show a strain response to acute intraocular pressure increases that differed from control eyes. This is in contrast to a previous finding in which rabbit eyes treated with prostaglandin analogues had a greater decrease in central corneal thickness in response to a sudden intraocular pressure increase compared with untreated corneas.
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* Address correspondence to this author at the Hospital Universitario Príncipe de Asturias, Carretera de Alcalá-Meco s/n. CP. 28805, Alcalá de Henares, Spain; Tel: +34 646 93 50 77; E-mail: firstname.lastname@example.org