The Open Ophthalmology Journal

ISSN: 1874-3641 ― Volume 14, 2020

The Thiol-Disulfide Homeostasis and Coenzyme Q10 in Conjunction with Vitamin E Effect on Retinopathy Prematurity

Muberra Akdogan1, *, Yasemin Ustundag2, Arzu Akdağ3, Salim Neselioglu4, Ozcan Erel4
1 Department of Ophthalmology, Faculty of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar 03320, Turkey
2 Department of Clinical Biochemistry, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa 16290, Turkey
3 Newborn Clinic, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa 16290, Turkey
4 Department of Clinical Biochemistry, Yildirim Beyazit University, 06760, Ankara, Turkey



This study was performed to determine whether one drop of topical administration of Coqun® (Coenzyme Q10 and Vitamin E)-a potent antioxidant-twice a day has any effect on the thiol-disulphide homeostasis-a novel oxidative stress marker in the Retinopathy Of Prematurity (ROP) disease course.


This was a prospective observational study comprising 28 infants with ROP at stage 2 and higher who followed up at the paediatric intensive care unit. Ferric reducing power of plasma (FRAP), albumin, ischemia-modified albumin (IMA) and thiol disulphide homeostasis levels were studied in the infants before and two weeks after Coqun® treatment.


The mean gestational age was 27 (24–32) weeks, the mean birth weight was 1,012±326 g and the mean duration of care in an incubator was 64±23 days. FRAP levels were 0.91±0.17 μmol/L, IMAs were 0.85±0.29, native thiols were 248±38.9 μmol/L and total thiols were 284±39.2 μmol/L, respectively, at the beginning of therapy.

FRAP levels 0.79±0.21(p= 0.006) μmol/L, IMAs 0.73±0.36(p = 0.096), native thiols 262±42.6(p = 0.164) μmol/L and total thiols 291±43.6(p = 0.344) μmol/L showed no difference after two weeks of therapy.


Thiol disulphide homeostasis levels do not change with Coqun® therapy during ROP course.

Keywords: Antioxidants, Coenzyme Q10, Retinopathy of Prematurity, Thiol, Vitamin E, FRAP.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 23
Last Page: 28
Publisher Id: TOOPHTJ-13-23
DOI: 10.2174/1874364101913010023

Article History:

Received Date: 13/12/2018
Revision Received Date: 07/02/2019
Acceptance Date: 06/03/2019
Electronic publication date: 26/03/2019
Collection year: 2019

© 2019 Akdogan et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Ophthalmology, Faculty of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar 03320, Turkey; E-mail:

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