1 Department of Ophthalmology, Faculty of Medicine, Afyonkarahisar Health Science University, Afyonkarahisar 03320, Turkey
2 Department of Clinical Biochemistry, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa 16290, Turkey
3 Newborn Clinic, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital, Bursa 16290, Turkey
4 Department of Clinical Biochemistry, Yildirim Beyazit University, 06760, Ankara, Turkey
This study was performed to determine whether one drop of topical administration of Coqun® (Coenzyme Q10 and Vitamin E)-a potent antioxidant-twice a day has any effect on the thiol-disulphide homeostasis-a novel oxidative stress marker in the Retinopathy Of Prematurity (ROP) disease course.
This was a prospective observational study comprising 28 infants with ROP at stage 2 and higher who followed up at the paediatric intensive care unit. Ferric reducing power of plasma (FRAP), albumin, ischemia-modified albumin (IMA) and thiol disulphide homeostasis levels were studied in the infants before and two weeks after Coqun® treatment.
The mean gestational age was 27 (24–32) weeks, the mean birth weight was 1,012±326 g and the mean duration of care in an incubator was 64±23 days. FRAP levels were 0.91±0.17 μmol/L, IMAs were 0.85±0.29, native thiols were 248±38.9 μmol/L and total thiols were 284±39.2 μmol/L, respectively, at the beginning of therapy.
FRAP levels 0.79±0.21(p= 0.006) μmol/L, IMAs 0.73±0.36(p = 0.096), native thiols 262±42.6(p = 0.164) μmol/L and total thiols 291±43.6(p = 0.344) μmol/L showed no difference after two weeks of therapy.
Thiol disulphide homeostasis levels do not change with Coqun® therapy during ROP course.
Keywords: Antioxidants, Coenzyme Q10, Retinopathy of Prematurity, Thiol, Vitamin E, FRAP.
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