The Open Ophthalmology Journal

ISSN: 1874-3641 ― Volume 14, 2020

Topical Cyclosporine (0.05%) for Management of Dry Eyes in Patients Undergoing Cataract Surgery-A Comparative Study

Sri Ganesh, Sheetal Brar, Sheetal N. Bagare*
Nethradhama Superspeciality Eye Hospital, Bangalore, India



To assess the efficacy of topical cyclosporine 0.05% in the management of cataract surgery induced dry eye.


This prospective, comparative, randomized, interventional study included 67 patients undergoing cataract surgery. The patients were randomized into three categories Group A: patients on topical lubricants and cyclosporine 0.05%, Group B: patients on topical lubricants only and Group C: patients not on any dry eye medication. Patients were given the respective treatment 2 weeks prior and 3 months after cataract surgery, along with an identical perioperative regimen of topical steroids, antibiotics and NSAIDs. Dry eye evaluation done 2 weeks pre-op, 1 week post-op and 3 months post-op consisted of a subjective questionnaire, tear osmolarity, Tear Break Up Time (TBUT) and Schirmer’s 1 without and with anaesthesia.


Pre-operatively, all the 3 groups were matched in terms of mean age, tear osmolarity, TBUT and Schirmer’s 1 without and with anaesthesia scores. At 3 months, patients treated with both topical lubricants and cyclosporine (0.05%)(Group A) showed improvement subjective questionnaire, tear osmolarity, TBUT and Schirmer’s 1 tests. Patients treated with lubricants only (Group B) showed a significant worsening in TBUT and tear osmolarity at 1 week, however, the values returned to baseline at 3 months.The control group (Group C) had the worst TBUT scores at the end of 3 months and showed the persistence of raised tear osmolarity, suggestive of a prolonged ocular inflammation resulting in patient dissatisfaction.


Topical cyclosporine (0.05%) may be a useful adjuvant to prevent and treat cataract surgery associated with dry eye symptoms, especially in patients with pre-existing dry eye disease.

Keywords: Cyclosporine, Dry eye, Tear osmolarity, Cataract surgery, Topical Cyclosporine, Tear Break Up Time (TBUT).

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 34
Last Page: 42
Publisher Id: TOOPHTJ-13-34
DOI: 10.2174/1874364101913010034

Article History:

Received Date: 09/12/2018
Revision Received Date: 21/03/2019
Acceptance Date: 04/04/2019
Electronic publication date: 30/04/2019

© 2019 Ganesh et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Nethradhama Superspeciality Eye Hospital, 256/14, Kanakapura main road, 7th block, Jayanagar, Bangalore- 560082, India; Tel: +91- 9916393219;Email:

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