The Open Ophthalmology Journal

ISSN: 1874-3641 ― Volume 13, 2019

Same-Site Deep Sclerectomy Re-Operation with Subconjunctival and Subscleral Collagen Matrix (Ologen™) and Minimal use of Mitomycin C

Pablo Díaz-Aljaro*, Jordi Loscos-Arenas, Pau Romera-Romero, Nevena Romanic-Bubalo, Stefano Grixolli-Mazzon, Valldeperas X
Hospital Universitari Germans Trias i Pujol, Carrer de Canyet S/N, Spain



This study aimed to evaluate the safety and efficacy of same-site Deep Sclerectomy (DS) re-operation with subconjunctival and subscleral collagen matrix (Ologen™) and minimal use of mitomycin C in cases of late failure blebs.


A prospective evaluation of consecutive patients on which same-site DS was performed with subconjunctival and subscleral collagen matrix (Ologen™) and minimal use of mitomycin C; all performed at a single university institution. Intraocular pressure (IOP), number of glaucoma medications, postoperative interventions, postoperative complications and surgical success were registered at 24 hours, 1, 6 and 12 months after the surgery.


Twenty-five eyes of 25 patients were included in this study. Time from first DS was 55.08 ± 28.16 months. Mean preoperative IOP was 20.88 ± 6.06 mmHg and it was reduced to 16.64 ± 4.02 mmHg, at 12 months after re-operation (p 0,007). At this final visit, requirements for topical medications dropped from a mean of 2.2 ± 1.0 to 0.72 ± 1.0 per patient and no medications were required in 60% of patients. Success was 36 % in criteria A (IOP ≤15mmHg), 72% in criteria B (IOP ≤18 mmHg) and 80 % in criteria C (IOP ≤15 mmHg), 12 months after the second surgery.


The same-site DS re-operation with subconjunctival and subscleral collagen matrix (Ologen®) and minimal use of mitomycin C is a safe and adequate technique for the reduction of IOP, especially when targeted IOP is not lower than 15mmHg.

Keywords: Glaucoma, Deep sclerectomy, Same site, Reoperation, Ologen, Collagen matrix, IOP.

Article Information

Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 43
Last Page: 50
Publisher Id: TOOPHTJ-13-43
DOI: 10.2174/1874364101913010043

Article History:

Received Date: 28/11/2018
Revision Received Date: 04/03/2019
Acceptance Date: 19/04/2019
Electronic publication date: 30/04/2019
Collection year: 2019

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© 2019 Díaz-Aljaro et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: ( This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Hospital Universitari Germans Trias i Pujol, Carrer de Canyet S/N, Spain; Tel: +34697889186;


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