Adverse Effects of the Oral Anticancer Drug S-1: Lacrimal Passage Impairment and Specific Features of Corneal Epitheliopathy

Sato, Ken-ichi; Nishimura, Shin-ichi

Adverse Effects of the Oral Anticancer Drug S-1: Lacrimal Passage Impairment and Specific Features of Corneal Epitheliopathy

Ken-ichi Sato^*, Shin-ichi Nishimura

Department of Ophthalmology, Nikko Memorial Hospital, Muroran, Hokkaido, Japan

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Identifiers and Pagination:

Year: 2013
Volume: 7
First Page: 85
Last Page: 86
Publisher ID: TOOPHTJ-7-85
DOI: 10.2174/1874364101307010085

Article History:

Received Date: 4/7/2013
Revision Received Date: 21/11/2013
Acceptance Date: 28/11/2013
Electronic publication date: 30/12/2013
Collection year: 2013

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© Sato and Nishimura; Licensee Bentham Open.

open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.

^* Address correspondence to this author at the Department of Ophthalmology, Nikko Memorial Hospital, Muroran, Hokkaido, Japan; Tel: +81-143-24-1331; Fax: +81-143-22-5296; E-mail: vze04311@nifty.ne.jp

We report the incidence of lacrimal passage impairment and specific features of corneal epitheliopathy as adverse effects of the oral anticancer drug S-1, and examine the relationship between the two pathologies. We conducted a retrospective chart review of 84 patients prescribed the anticancer drug S-1. The incidence of lacrimal passage impairment and corneal epitheliopathy was 8% and 6%, respectively. Three patients experienced both pathologies, demonstrating a moderate probability of both occurring in the same patient (kappa coefficient = 0.46). The findings show that lacrimal passage impairment and specific features of corneal epitheliopathy are likely to occur in the same individual as adverse effects of S-1.

Keywords:: Antineoplastic agents, adverse effects, lacrimal duct obstruction, corneal diseases.

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Tatsuya Mimura
Department of Ophthalmology
Teikyo University School of Medicine
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RESEARCH ARTICLE

Adverse Effects of the Oral Anticancer Drug S-1: Lacrimal Passage Impairment and Specific Features of Corneal Epitheliopathy

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Abstract

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