Death by Water: Precautionary Water Submersion for Intravitreal Injection of Retinoblastoma Eyes
Jasmine H Francis*, 1, Xiaoliang L Xu 2, Y. Pierre Gobin 3, Brian P Marr 1, 4, Scott E Brodie 5, David H Abramson 1, 4
1 Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
2 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY, USA
3 Service of Interventional Neuroradiology, Departments of Neurosurgery, Neurology and Radiology, Weill Cornell Medical College of New York-Presbyterian Hospital, New York, NY, USA
4 Department of Ophthalmology, Weill Cornell Medical College of New York-Presbyterian Hospital, New York, NY, USA
5 Department of Ophthalmology, Mount Sinai School of Medicine, New York, NY, USA
There is growing interest in intravitreal injections of chemotherapy for retinoblastoma. However, concerns for potential tumor seeding through the needle track has prompted the use of risk-reducing precautionary methods. Presented here is a novel technique, which can be easily replicated, requires minimal sophisticated equipment and with laboratory data supporting its concept. Sterile distilled water submersion for 3 minutes renders retinoblastoma cells nonviable and can be employed as a precautionary method following intravitreal injection in the technique described here.
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
* Address correspondence to this author at the Ophthalmic Oncology Service, Memorial Sloan-Kettering Cancer Center, 70 East 66th Street, New York, NY 10065, USA; Tel: (212) 744 1700; Fax: (212) 734 2553;