RESEARCH ARTICLE


CoCrMo alloy vs. UHMWPE Particulate Implant Debris Induces Sex Dependent Aseptic Osteolysis Responses In Vivo using a Murine Model



Stefan Landgraeber1, Lauryn Samelko2, Kyron McAllister2, Sebastian Putz1, Joshua.J. Jacobs2, Nadim James Hallab2, *
1 Department of Orthopaedics, University Hospital Essen, University of Duisburg-Essen, Hufelandstrabe 55, 45122 Essen, Germany
2 Department of Orthopedic Surgery, Rush University Medical Center, Chicago, IL, U.S.A


Article Metrics

CrossRef Citations:
7
Total Statistics:

Full-Text HTML Views: 860
Abstract HTML Views: 430
PDF Downloads: 270
ePub Downloads: 221
Total Views/Downloads: 1781
Unique Statistics:

Full-Text HTML Views: 525
Abstract HTML Views: 305
PDF Downloads: 206
ePub Downloads: 183
Total Views/Downloads: 1219



Creative Commons License
© 2018 Landgraeber et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Department of Orthopedic Surgery, Rush University Medical Center, 1735 W Harrison, Chicago, IL 60612, U.S.A; Tel: 312-942-7079; Fax: 312-942-8828; E-mail: nhallab@rush.edu


Abstract

Background:

The rate of revision for some designs of total hip replacements due to idiopathic aseptic loosening has been reported as higher for women. However, whether this is environmental or inherently sex-related is not clear.

Objective:

Can particle induced osteolysis be sex dependent? And if so, is this dependent on the type of implant debris (e.g. metal vs polymer)? The objective of this study was to test for material dependent inflammatory osteolysis that may be linked to sex using CoCrMo and implant grade conventional polyethylene (UHMWPE), using an in vivo murine calvaria model.

Methods:

Healthy 12 week old female and male C57BL/6J mice were treated with UHMWPE (1.0um ECD) or CoCrMo particles (0.9um ECD) or received sham surgery. Bone resorption was assessed by micro-computed tomography, histology and histomorphometry on day 12 post challenge.

Results:

Female mice that received CoCrMo particles showed significantly more inflammatory osteolysis and bone destruction compared to the females who received UHMWPE implant debris. Moreover, females challenged with CoCrMo particles exhibited 120% more inflammatory bone loss compared to males (p<0.01) challenged with CoCrMo implant debris (but this was not the case for UHMWPE particles).

Conclusion:

We demonstrated sex-specific differences in the amount of osteolysis resulting from CoCrMo particle challenge. This suggests osteo-immune responses to metal debris are preferentially higher in female compared to male mice, and supports the contention that there may be inherent sex related susceptibility to some types of implant debris.

Keywords: Osteolysis, Aseptic loosening, Innate immune reactivity, Implant material, Bioreactivity, Inflammatory osteolysis, Wear debris.