Alane Beatriz Vermelho, Marta Helena Branquinha, Claudia M. D’Ávila-Levy, André Luis Souza dos Santos, Edilma Paraguai de Souza Dias, Ana Cristina Nogueira de Melo
Departamento de Microbiologia,
Geral, Instituto de Microbiologia Prof. Paulo de Góes, Universidade
Federal do, Rio de Janeiro-UFRJ /CCS, Bloco I, Cidade Universitária, Ilha
do Fundão, Rio, de Janeiro, R.J, Brazil.
Abstract HTML Views: 252 PDF Downloads: 137 Total Views/Downloads: 735
Abstract HTML Views: 177 PDF Downloads: 112 Total Views/Downloads: 519
In this review, we report the recent developments in the characterization of peptidases and their possible biological
functions in the Trypanosomatidae family. The focus will be on peptidases from Trypanosoma cruzi, Leishmania
spp., African trypanosomes and plant and insect trypanosomatids. There are numerous events in parasite development
where the involvement of peptidases has been established, and they will be approached in the present review. Also in this
review we will discuss the central roles have been proposed for peptidases in diverse processes such as virulence, host cell
interaction and invasion, catabolism of host proteins, differentiation, cell cycle progression and both stimulation and evasion
of host immune responses.