1 Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria
2 Department of Endocrinology, Faculty of Medicine, Damascus University, Damascus, Syria
Obestatin is a novel hormone derived from preproghrelin, which was reported to inhibit appetite and gastric motility.
This study aimed to investigate plasma obestatin levels in obese patients with T2D patients, which had not been studied clearly in last researches.
23 normal weight subjects, 35 obese subjects and 31 obese patients with T2D participated in the study, the body mass index was calculated. Fasting glucose and insulin levels were measured and the homeostasis model assessment of insulin resistance (HOMA-IR) was determined. Plasma obestatin levels were measured with enzyme-linked immune sorbent assay (ELISA). The relationship between plasma obestatin levels and biochemical parameters was also analyzed.
Fasting obestatin was significantly lower in obese patients with T2D, comparing to control subjects (mean=6.35 vs12.38ng/ml) and to the non-patients obese group (mean=6.35 vs 7.76 ng/ml). Obestatin levels correlated significantly and negatively with BMI (R=-0. 451; P=0. 01), basal insulin levels (R=-0.737, P<0.0001) and HOMA-IR (R=-0. 764, P<0.0001) in diabetic patients.
Our results suggest that obestatin may contribute to body weight regulation, and insulin sensitivity could be affected by obestatin levels.
Keywords: Obestatin, BMI, HOMA-IR, Type 2 diabetes mellitus, Homeostasis, Insulin.
open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
* Address correspondence to this author at the Department of Biochemistry and Microbiology, Faculty of Pharmacy, Damascus University, Damascus, Syria, Tel: +963937276440; E-mail: Dr.email@example.com