The present study aimed to examine the association of trait anxiety and social desirability (SOD) with granulocyte (GRA) and lymphocyte (LYM) counts in healthy adults. Subjects were 23 (9 males and 14 females) eligible adults. Trait anxiety and SOD were assessed using the Anxiety and Lie Scores of the Manifest Anxiety Scale (MAS), respectively. White blood cells were counted by flow cytometry. Data were analyzed by logistic regression analyses. The results showed that the odds ratio (OR) of MAS score was significant for prediction of GRA count (OR: 1.399, p=0.032) and also for neutrophil (NEU) count (OR: 1.381, p=0.040). The OR of Lie Scale scores was significant for LYM count (OR: 0.165, p=0.036) and also for GRA count (OR: 1.879, p=0.048). The present study suggests that healthy subjects with higher trait anxiety have a higher GRA count.