This article addresses the links and interactions between the neuroscience parallel line of theories and the parallel line of mental activity and thinking. An argument is made that the most fundamental biological entity, the human genome, provides a pathway of mind-body functional coordination via a double helix metaphor. Brief selections of neuroscience and psychological theories associated with the characteristics of higher thinking are presented. Advantages of tracing the double-helix/genome pathway to mind -body issues are discussed. A modification is proposed to reflect the unique development of speech and language in human beings. Their effects on thinking and communication warrant a unique avenue of investigation.