First of all we must consider what Osteoporosis is and who is affected by it. We analyze the most common therapies (Biphosfonates, etc.) employed in this field and what their side effects are like ONJ; basically no evidence based of medicine is existing at the moment about ONJ. Patients affected by Osteoporosis and undergoing Biphosfonate therapies that need any oral surgery in general, and implant treatment in particular, could be considered as more risky patients compared with normal patients, but once again not much data is available. We verify if there are some safety precautions to take before treating these patients and if there are some procedures to avoid; considering the important rule that implant treatment should have nowadays for the quality of life of the patients. Finally, we discuss if there are existing or will be present in the future on the market some specific drugs, which would be able to increase the Osteo-integration and bone healing of patients affected by Osteoporosis.