The distribution behavior of amlodipine enantiomers in a two-phase system containing tartaric acid derivatives
in organic phase and beta-cyclodextrin (β-CD) derivatives in aqueous phase has been studied. The effect of extraction
equilibrium time, influence of different alkyl chains of tartaric acids, types of beta-cyclodextrin derivatives, organic
solvents and buffer pH were investigated. It was found that hydroxypropyl- β-cyclodextrin (HP-β-CD) has the strongest
recognition ability among three β-CD derivatives of HP-β-CD, hydroxyethyl-β-cyclodextrin (HE-β-CD) and methylated-
β-cyclodextrin (Me-β-CD) while D-diisopropyl tartrate has the strongest ability among four tartaric acid derivatives of Ldiisopropyl
tartrate, D-diisopropyl tartrate, L-diethyl tartrate and D-diethyl tartrate. The distribution coefficient and
enantioselectivity, α gave an optimum value at pH 5.0.
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