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    ISSN: 2210-2892 ― Volume 10, 2020

    Phase Transitions of Ipidacrine Hydrochloride Polymorphs and Hydrates


    The Open Conference Proceedings Journal, 2011, 2: 21-27

    A. Dubnika, K. Veldre, A. Actins, J. Lescenko

    University of Latvia, Department of Chemistry, Kr.Valdemara Str. 48, Riga, LV-1053, Latvia.

    Electronic publication date 28/4/2011
    [DOI: 10.2174/2210289201102010021]




    Abstract:

    Ipidacrine hydrochloride is pharmaceutically active compound that forms variety of crystalline modifications which differs by solvent type and content in crystalline structure. These crystalline forms analyzed by powder x-ray diffraction, differential thermal analysis, thermogravimetry and Karl Fisher titration.

    Obtained crystalline forms include two monohydrates, two hemihydrates, two anhydrous forms, two non-stoichiometric hydrates and mixed solvates with octanol and water and methanol and water, solvate with chloroform and dimethylformamide.


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