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The seed of Sandoricum koetjape (Burm.f.) Merr., a member of Family Meliaceae, had been screened for its phytochemcial components and extracted using hexane, methanol, and water for antimicrobial activity towards three bacteria, Pseudomonas eruginosa, Bacillus subtilis, and Staphylococcus aureus. Phytochemical screening showed that the S. koetjape’s seeds contain high amount of alkaloid and flavonoid. The crude methanol extracts showed inhibition zones towards the three bacteria with minimal inhibition zones of 0.25 mgL-1 for B.subtilis and of 0.50 mgL-1 for both P.aeroginosa and S.aureus.