The Open Conference Proceedings Journal
(Biological Sciences, Chemical Sciences, Physical Sciences, Medicine, Engineering & Technology)
(Discontinued)
ISSN: 2210-2892 ― Volume 10, 2020
Flavonoid Analogues Isolated from the Stem Bark of Malaysian Polyalthia Cauliflora VAR. Cauliflora (Annonaceae) with Anticancer Properties
The Open Conference Proceedings Journal, 2013, 4: 207
Nurunajah Ab Ghani, Norizan Ahmat, Nor Hadiani Ismail, Asmah Alias, Nik Khairunissa, Nik Abdullah Zawawi, Siti Khadijah Sulaiman
Atta-ur-Rahman Institute for Natural Product Discovery, Level 9, FF3, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor.
Electronic publication date 1/3/2013
[DOI: 10.2174/2210289201304010207]
Abstract:
Phytochemical study on the stem bark of Polyalthia cauliflora var. cauliflora obtained from Pahang, Malaysia has been conducted. The separation of the chemical components were carried out by various chromatography techniques and their structures were elucidated by spectroscopic methods including nuclear magnetic resonance (1D and 2D NMR) as well as gas chromatography-mass spectrometry. Five flavones and two chalcones were isolated and has been identified as 3,7-dimethoxy- 5-hydroxyflavone (1), 5,8-dihydroxy-6,7-dimethoxyflavone (2), tetrochrysin (3), 6,7-dimethoxy-5-hydroxyflavone (4), 5- hydroxy-3,7,8-trimethoxyflavone (5), 2’,4’-dihydroxy-3’-methoxychalcone (6) and 2’,6’-dihydroxychalcone (7). Isolated chalcone, 2’,4’-dihydroxy-3’-methoxychalcone (6) was tested against three cell lines. Compound (6) shows active activity against HL-60 with IC50 = 5.1 μg/ml and moderate activity with IC50 12.2 μg/ml and 12.5 μg/ml against HeLa and MCF-7, respectively.