The Open Conference Proceedings Journal
(Biological Sciences, Chemical Sciences, Physical Sciences, Medicine, Engineering & Technology)
(Discontinued)
ISSN: 2210-2892 ― Volume 10, 2020
Phytochemical Study on Alkaloids From Bark of Alseodaphne perakensis (Lauraceae) and their Bioactivity
The Open Conference Proceedings Journal, 2013, 4: 218
Mahfuzah Md Nazimuddin , Muhammad Hafiz Husna Hasnan , Kartini Ahmad , Khalijah Awang , A. Hamid A. Hadi , Mohd Azlan Nafiah
Department of Chemistry, Faculty of Science and Mathematics, University of Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia.
Electronic publication date 01/3/2013
[DOI: 10.2174/2210289201304010218]
Abstract:
The purpose of this study was to isolate and identify compounds from the bark of Alseodaphne perakensis (Lauraceae) which commonly known as Medang to validate and evaluate the use of this species in antimalaria activity. The comprising compounds from the dichloromethane crude extract were separated using column chromatography and the structures of the compounds were elucidated using spectroscopic analysis. The identified compounds were aporphine alkaloids; corydine 1 and oxohernagine 2. These isolated compounds show IC50 values 0.404µg/ml and 0.738µg/ml, respectively against Plasmodium falciparum, K1 isolate (resistant strain).
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