The Open Conference Proceedings Journal
(Biological Sciences, Chemical Sciences, Physical Sciences, Medicine, Engineering & Technology)
(Discontinued)
ISSN: 2210-2892 ― Volume 10, 2020
A new Fistularin-3 Derivative from an Australian Sponge Pseudoceratinasp.
The Open Conference Proceedings Journal, 2013, 4: 41
Pinus Jumaryatno, Tina Skinner-Adams, Katherine T. Andrews, Rohan A. Davis, Joanne T. Blanchfield, Mary J. Garson
Pharmacy Department, Faculty of Mathematic and Natural Sciences, Universitas Islam Indonesia, Yogyakarta 55584, Indonesia.
Electronic publication date 1/3/2013
[DOI: 10.2174/2210289201304010041]
Abstract:
Chemical investigation of an Australian marine sponge, Pseudoceratina sp., collected from Mooloolaba South-East Queensland has provided a series of bromotyrosine metabolites from a simple modified tyrosine to more elaborate linear compounds. Six known compounds, (+)-aeroplysinin-1 (1), a mixture of 19-deoxyfistularin-3 (2) and 11-deoxyfistularin-3 (3), 11,19- dideoxyfistularin-3 (4), aerothionin (5) and homoaerothionin (6) have been isolated together with a new fistularin-3 derivative, 11-deoxy-19-ketofistularin-3 (7). The structures of all compounds were characterised using 1D and 2D NMR techniques, MS and by comparison with literature data. Two selected fistularin-3 derivative metabolites 4 and 7 were screened for in vitro activity against chloroquine-sensitive (3D7) P. falciparum malaria parasites and showed antimalarial activity with IC50 values of 5.4 and 2.8 μM, respectively.