The Open Conference Proceedings Journal


(Biological Sciences, Chemical Sciences, Physical Sciences, Medicine, Engineering & Technology)



ISSN: 2210-2892 ― Volume 10, 2019

Antiplasmodial Active Compound from Hernagine Type of Aporphine Alkaloids


The Open Conference Proceedings Journal, 2013, 4: 42

Muhammad Hafiz Husna Hasnan, Kartini Ahmad, Mohamad Nurul Azmi Mohamad Taib, Khalijah Awang, A. Hamid A. Hadi, Mohd Azlan Nafiah

Department of Chemistry, Faculty of Science and Mathematics, Universiti Pendidikan Sultan Idris, 35900 Tanjong Malim, Perak, Malaysia.

Electronic publication date 1/3/2013
[DOI: 10.2174/2210289201304010042]

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Abstract:

Phytochemistry investigation on alkaloids from Alseodaphne pendulifolia Gamb. yielded 3 types of aporphines; Hernagine 1, N-methylhernagine 2, and Oxohernagine 3. Preliminary screening on alkaloids crude extract from this species exhibited an antiplasmodial activity (0.804μg/ml IC50) against Plasmodium falciparum, K1 isolate (resistant strain). Further investigation on isolated compound were found to possess antiplasmodial activity (0.738 - 1.814μg/ml IC50). This study involves extraction, separation by using various chromatography methods and structural elucidation by spectroscopic technique such as IR, NMR including 1D, 2D-NMR and MS.


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