The Open Conference Proceedings Journal
(Biological Sciences, Chemical Sciences, Physical Sciences, Medicine, Engineering & Technology)
(Discontinued)
ISSN: 2210-2892 ― Volume 10, 2020
Triterpenes with 5-Lipoxigenase (5-LOX) and Xanthine Oxidase (XOD) Inhibitory Activity from the Stem of Ficus Aurantiaca Griff
The Open Conference Proceedings Journal, 2013, 4: 73
Shukranul Mawa, Khairana Husain, Ibrahim Jantan
Drug & Herbal Research Centre, Faculty of Pharmacy, University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Electronic publication date 1/3/2013
[DOI: 10.2174/2210289201304010073]
Abstract:
Two compounds identified as taraxerone 1 and taraxerol 2 have been isolated from Ficus aurantiaca. There has been no previous report on the chemical constituents and biological activities of this plant. Compounds 1 and 2 were isolated from EA extract of the stem of F. aurantiaca. The structures were evaluated based on spectroscopic methods including nuclear magnetic resonance (NMR), UV, IR and mass spectrometry and comparison with the published information in the literature. The 5-lipoxenase enzyme inhibition assay showed that compound 1 and 2 have 5-LOX inhibitory activity with IC50 of 21.67 ± 6.52 (μg/mL) and 23.07 ± 7.30 (μg/mL) respectively. On the other hand compound 1 and 2 exhibited significant XOD inhibitory activity with IC50 of 8.72±1.79 (μg/mL) and 12.87±5.10 (μg/mL) respectively.