Uni Gamayani1, *, Chandra Calista1, Anam Ong1, Pandji Irani Fianza2, Ramdan Panigoro3
1 Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Jalan Pasteur no 38, Bandung, Indonesia
2 Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Jalan Pasteur no 38, Bandung, Indonesia
3 Department of Biomedical Science, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin General Hospital, RSP Unpad, Jalan Eijkman No 38, Bandung, Indonesia
Many studies on thalassemia patients have shown cognitive decline that may affect the patients’ life. To clarify the cognitive value in thalassemia patients, we performed a neuropsychological test on these patients.
This was a prospective observational analytic with case control study involving 40 thalassemia patients and 40 controls similar for age, sex, and education. All subjects underwent a comprehensive neuropsychological test including visual cognitive assessment.
Compared to controls, patients with thalassemia aged 15-47 years old had poorer results in world list recall (p=0.026), TMT-B (p=0.042), clock drawing test (p=0.049), ADAS-Cog (p=0.014), logical memory (p=0.001) and digit symbol (p<0.001). These results indicate that thalassemia patients have significantly lower attention, verbal memory capability, and executive function.
Our findings concluded that patients with thalassemia have impaired multiple cognitive domains.
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* Address correspondence to this author at the Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin General Hospital, Jalan Pasteur no 38, Bandung, Indonesia, E-mail: firstname.lastname@example.org