The Open Rheumatology Journal




ISSN: 1874-3129 ― Volume 13, 2019
RESEARCH ARTICLE

Predictor of the Simplified Disease Activity Index 50 (SDAI 50) at Month 3 of bDMARD Treatment in Patients with Long-Established Rheumatoid Arthritis



Yusuke Miwa1, *, Mayu Saito1, Hidekazu Furuya1, Ryo Yanai2, Tsuyoshi Kasama2
1 Division of Rheumatology, Department of Medicine, Showa University School of Medicine, Tokyo, Japan
2 Division of Rheumatology, Department of Medicine, Showa University Koto-Toyosu Hospital, Tokyo, Japan

Abstract

Objectives:

The Simplified Disease Activity Index (SDAI) 50 has good agreement with European League Against Rheumatism (EULAR) response measures for early Rheumatoid Arthritis (RA). There have been reports on early RA, but not on long-established RA. In this study, we analysed the relationships between various baseline factors and SDAI 50 after three months of treatment with biological disease-modifying antirheumatic drugs (bDMARDs) to determine the prognostic factors for long-established RA.

Methods:

Subjects were 260 RA patients who had been treated with bDMARDs for 3 months. The following characteristics were investigated: Patient backgrounds, the erythrocyte sedimentation rate (ESR), C-reactive protein and serum matrix metalloproteinase-3 levels, SDAI scores, and health assessment questionnaire disability index and short form-36 scores. As a primary outcome index, the SDAI response was defined as a 50% reduction in the SDAI score between baseline and 3 months (SDAI 50).

Results:

Baseline values of disease duration (odds ratio: 0.942, 95% CI: 0.902-0.984), smoking history (odds ratio: 2.272, 1.064-4.850), 28-tender joint count (odds ratio: 0.899, 0.827-0.977), evaluator's global assessment (odds ratio: 1.029, 1.012-1.047) and ESR (odds ratio: 1.015, 1.001-1.030) were determined to be significant factors based on logistic regression analysis.

Conclusion:

Our study demonstrated that RA patients with shorter disease duration, no smoking, and higher RA disease activity are more likely to achieve SDAI 50 through bDMARD treatment.

Keywords: Rheumatoid arthritis, SDAI 50, Response, bDMARDs, EULAR, SDAI.


Article Information


Identifiers and Pagination:

Year: 2017
Volume: 11
First Page: 106
Last Page: 112
Publisher Id: TORJ-11-106
DOI: 10.2174/1874312901711010106

Article History:

Received Date: 15/05/2017
Revision Received Date: 21/06/2017
Acceptance Date: 12/09/2017
Electronic publication date: 30/09/2017
Collection year: 2017

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© 2017 Miwa et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


* Address correspondence to this author at the Division of Rheumatology, Showa University School of Medicine, 1-5-8 Hatanodai, Shinagawa-ku, Tokyo, Japan 142-8666; Tel: +81-3-3784-8942; Fax: +81-3-3784-8946; E-mail: y.miwa@mbf.ocn.ne.jp


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