Interethnic Variations and Clinical Features of Spondyloarthropathies in a Middle Eastern Country
Mohammed Kamil Quraishi1, *, Humeira Badsha2, Bhavna Khan3, Muhammad Shahzeb4, Srilakshmi Hegde5, Ayman Mofti5, Kong Kok Ooi6
1 Department of Urology, Medway Maritime Hospital, Kent, England, UK
2 Department of Rheumatology. Dr. Humeira Badsha Medical Center, Dubai, UAE.
3 Integrated Rheumatology and Arthritis Centre, Dubai Healthcare City, Dubai.
4 Department of Medicine, Jinnah Medical College Hospital, Karachi, Pakistan.
5 Department of Rheumatology, Al Biraa Arthritis & Bone Center, Dubai, UAE.
6 Department of Rheumatology, Tan Tock Seng Hospital, Singapore
The study aimed to demonstrate the interethnic differences and clinical features of Spondyloarthropathy(SpA) patients in a diverse Middle Eastern Country.
A retrospective review of medical records to collect the required data was conducted for SpA patients at two study institutions in the United Arab Emirates.
Of 141 SpA patients found, 88 AS(Ankylosing Spondylitis) patients and 53 ‘other SpA’ patients were identified. Males constituted 81% of AS and 55% of ‘other SpA’ patients. Patients with AS and ‘other SpA’ had a mean age of symptom onset of 28 and 34 years, respectively.
49% and 40% of AS and ‘other SpA’ patients had a history of Anti-TNF therapy usage. Enthesitis and Uveitis were noted in 16% and 18% of AS patients whilst 53% and 11% in ‘other SpA’ patients, respectively.
Caucasian, Indian Subcontinent and Arabs constituted 93% of our cohort. Mean age of onset of symptoms in the Indian Subcontinent ‘other SpA’ group was much greater than the other two ethnicities. Duration of symptoms to diagnosis was 3.5 and 4 years in AS and other SpA patients' respectively. HLA-B27 positivity was found in 53%, 80% and 93% of Arab, Indian Subcontinent and Caucasian AS patients, respectively, whilst seen in 50%, 25% and 33% of the same respective ethnicties in ‘other SpA’ patients.
This study on 141 patients is the largest to analyse inter-ethnic variations in SpA patients in the region. Our cohort shows a short delay in diagnosis with a relatively higher Anti-TNF usage.
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* Address correspondence to this author at the Department of Urology, Medway Maritime Hospital, Windmill Road, Gillingham, Kent, UK ME7 5NY; E-mail: MKQURAISHI@doctors.org.uk