Assessment of Mean Platelet Volume in Patients with Systemic Lupus Erythematosus
Lisandra Torres Hartmann1, *, Ana Paula Alegretti1, Alice Beatriz Mombach Pinheiro Machado1, Eduardo Ferreira Martins2, Rafael Mendonça da Silva Chakr2, Andrese Aline Gasparin2, Odirlei André Monticielo2
1 Department of Clinical Pathology, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brasil
2 Division of Rheumatology, Department of Internal Medicine, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brasil
The Mean Platelet Volume (MPV) is a platelet activation biomarker that has been recently correlated with disease activity in SLE. We aimed to evaluate the MPV in patients with SLE comparing it with healthy individuals, to study the correlation between MPV and SLE Disease Activity Index (SLEDAI) in SLE patients and to analyze possible correlation between MPV and Erythrocyte Sedimentation Rate (ESR), C-Reactive Protein (CRP), and complement components C3 and C4.
This is a cross-sectional study in which 81 patients with SLE according to the American College of Rheumatology (ACR) diagnostic classification criteria and 58 healthy controls were included. Active disease was defined as SLEDAI>0.
Patients with active SLE had decreased MPV when compared to inactive disease group (10.0±0.7fL vs. 10.7±1.0fL, p=0.005, respectively) and when compared to control group (10.9±1.0fL, p<0.001). Our study found a weak negative correlation between the SLEDAI and the MPV (r=-0.29, p=0.009). There was no correlation between MPV and CRP, ESR, C3 and C4. Also, no correlation between SLEDAI and CRP, ESR, C3 and C4 was found.
MPV decreases in patients with active SLE and is inversely correlated with SLEDAI.
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* Address for correspondence to this auther at the Serviço de Patologia Clínica do Hospital de Clínicas de Porto Alegre - HCPA, Rua Ramiro Barcelos, 2350 – Largo Eduardo Zaccaro Faraco, 2º Andar Laboratório de Patologia Clínica, Porto Alegre, Rio Grande do Sul, Brasil, Zip Code: 90035-903, Tel: +555133598316; E-mail: firstname.lastname@example.org