RESEARCH ARTICLE


Association of Polymorphisms in the DNA Repair Genes XRCC1 and XRCC3 with Systemic Lupus Erythematosus



Cristhiane A. Leite Da Silva1, 5, *, Marcial F. Galera2, Regiane R. Festi3, Mariano M. Espinosa4, Vander Fernandes1, Paula H. Blaskievicz1, Eliane P. Dias5
1 Master Program in Environment and Health, University of Cuiabá, Av. Manoel José de Arruda, 3100 - Jardim Europa, Cuiabá-MT, 78025-190, Brazil
2 Department of Pediatrics, School of Medicine Cuiaba, Federal University of Mato Grosso, Av. Manoel José de Arruda, 3100 - Jardim Europa, Cuiabá-MT, 78025-190, Brazil
3 Department of Genetic, School of Medicine Cuiaba, University of Cuiabá, Av. Fernando Correa da Costa, 2.367 – Bairro: Boa Esperança CEP: 78060-900, Brazil
4 Department of Statistics, Institute of Exact Sciences, Federal University of Mato Grosso, Av. Fernando Correa da Costa, 2.367 – Bairro: Boa Esperança CEP: 78060-900, Brazil
5 Department of Pathology, School of Medicine, Federal Fluminense University, Rua Rua Marquês do Paraná, 303 Centro. CEP 24033 900, Brazil

Article Information


Identifiers and Pagination:

Year: 2019
Volume: 13
First Page: 15
Last Page: 21
Publisher ID: TORJ-13-15
DOI: 10.2174/1874312901913010015

Article History:

Received Date: 02/10/2018
Revision Received Date: 30/01/2019
Acceptance Date: 08/02/2019
Electronic publication date: 28/02/2019
Collection year: 2019

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Creative Commons License
© 2019 Da Silva et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: (https://creativecommons.org/licenses/by/4.0/legalcode). This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this Master Program in Environment and Health, University of Cuiabá, Av. Manoel José de Arruda, 3100 - Jardim Europa, Cuiabá - MT, 78025-190, Brazil; Email: cristhianeleite@hotmail.com


Abstract

Background:

Evidence suggests that DNA damage is implicated in the development of Systemic Lupus Erythematosus (SLE).

Objective:

Investigate the possible association of polymorphisms in the DNA repair genes XRCC1 and XRCC3 with SLE and its clinical and laboratory features.

Methods:

This is a case-control study comparing the polymorphisms in the DNA repair genes XRCC1 and XRCC3 in SLE patients and control individuals. Genotyping for DNA repair genes was performed by polymerase chain reaction-restriction fragment length polymorphism in 76 patients and 82 healthy control individuals.

Results:

Our data indicated that the genotype frequencies in patients with the XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms were similar to those observed in the control group (p > 0.05). However, the frequencies of the 399Gln allele (p = 0.023, OR = 0.58, 95% CI = 0.36–0.93) and 241Met allele (p = 0.0039, OR = 0.59, 95% CI = 0.36–0.98) were significantly lower in the patients than those in the control subjects.

Conclusion:

We demonstrated that 399Gln and 241Met alleles may play a protective role in SLE susceptibility.

Keywords: Genetic, DNA repair, Polymorphism, XRCC1, XRCC3, Systemic lupus erythematosus.