Association of Polymorphisms in the DNA Repair Genes XRCC1 and XRCC3 with Systemic Lupus Erythematosus
Cristhiane A. Leite Da Silva1, 5, *, Marcial F. Galera2, Regiane R. Festi3, Mariano M. Espinosa4, Vander Fernandes1, Paula H. Blaskievicz1, Eliane P. Dias5
1 Master Program in Environment and Health, University of Cuiabá, Av. Manoel José de Arruda, 3100 - Jardim Europa, Cuiabá-MT, 78025-190, Brazil
2 Department of Pediatrics, School of Medicine Cuiaba, Federal University of Mato Grosso, Av. Manoel José de Arruda, 3100 - Jardim Europa, Cuiabá-MT, 78025-190, Brazil
3 Department of Genetic, School of Medicine Cuiaba, University of Cuiabá, Av. Fernando Correa da Costa, 2.367 – Bairro: Boa Esperança CEP: 78060-900, Brazil
4 Department of Statistics, Institute of Exact Sciences, Federal University of Mato Grosso, Av. Fernando Correa da Costa, 2.367 – Bairro: Boa Esperança CEP: 78060-900, Brazil
5 Department of Pathology, School of Medicine, Federal Fluminense University, Rua Rua Marquês do Paraná, 303 Centro. CEP 24033 900, Brazil
Evidence suggests that DNA damage is implicated in the development of Systemic Lupus Erythematosus (SLE).
Investigate the possible association of polymorphisms in the DNA repair genes XRCC1 and XRCC3 with SLE and its clinical and laboratory features.
This is a case-control study comparing the polymorphisms in the DNA repair genes XRCC1 and XRCC3 in SLE patients and control individuals. Genotyping for DNA repair genes was performed by polymerase chain reaction-restriction fragment length polymorphism in 76 patients and 82 healthy control individuals.
Our data indicated that the genotype frequencies in patients with the XRCC1 Arg399Gln and XRCC3 Thr241Met polymorphisms were similar to those observed in the control group (p > 0.05). However, the frequencies of the 399Gln allele (p = 0.023, OR = 0.58, 95% CI = 0.36–0.93) and 241Met allele (p = 0.0039, OR = 0.59, 95% CI = 0.36–0.98) were significantly lower in the patients than those in the control subjects.
We demonstrated that 399Gln and 241Met alleles may play a protective role in SLE susceptibility.
Keywords: Genetic, DNA repair, Polymorphism, XRCC1, XRCC3, Systemic lupus erythematosus.
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