RESEARCH ARTICLE
Synovial Tissue Response to Treatment in Psoriatic Arthritis
Veronica Codullo1, 2, Iain B McInnes*, 1
Article Information
Identifiers and Pagination:
Year: 2011Volume: 5
Issue: Suppl 1
First Page: 133
Last Page: 137
Publisher ID: TORJ-5-133
DOI: 10.2174/1874312901105010133
Article History:
Received Date: 27/3/2011Revision Received Date: 3/10/2011
Acceptance Date: 7/10/2011
Electronic publication date: 30/12/2011
Collection year: 2011
open-access license: This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Abstract
Following its validation and wide application in rheumatoid arthritis (RA), synovial tissue analysis has recently been applied to studies on Psoriatic Arthritis (PsA). Such studies aim to thereby clarify its distinctive features and the nature of specific responses upon administration of disease modifying anti-rheumatic drug (DMARD) or biologic agents. In consequence, insights to disease pathogenesis, drugs’ mechanisms of action (MOA) and biomarkers of response have emerged. Data from pilot and open-label studies, and recently from randomized controlled trials, have helped in refining the therapeutic approaches to PsA patients, by improving understanding of MOA and in provision of biomarkers of response. The availability of less invasive and reproducible analysis techniques to obtain and evaluate synovial biopsies will further enhance the utility of this approach in due course.
