Arian Laurence1, Marko Pesu2, 3, Olli Silvennoinen2, 3, John O’Shea*, 1
1 Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
2 Institute of Biomedical Technology, FI-33014 University of Tampere, Finland
3 Centre for Laboratory Medicine, FI-33520 Tampere University Hospital, Finland
Janus kinases (Jaks) are critical signaling elements for a large subset of cytokines. As a consequence they play
pivotal roles in the patho-physiology of many diseases including neoplastic and autoimmune diseases. Small molecule Jak
inhibitors as therapeutic agents have become a reality and the palette of such inhibitors will likely expand. This review
will summarize our current knowledge on these key enzymes and their associated pharmaceutical inhibitors.
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* Address correspondence to this author at the Molecular Immunology and Inflammation Branch, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA; Tel: +1 301-496-2612; Fax: +1 301-480-6372; E-mail: firstname.lastname@example.org