Laboratory Test Abnormalities are Common in Polymyositis and
Dermatomyositis and Differ Among Clinical and Demographic Groups
Rita Volochayev 1, Gyorgy Csako 2, Robert Wesley 2, Lisa G Rider 1, Frederick W Miller*, 1
1 Environmental Autoimmunity Group, Program of Clinical Research, National Institute of Environmental Health
Sciences, National Institutes of Health, HHS, Bethesda, Maryland, USA
2 The Clinical Center, National Institutes of Health, HHS, Bethesda, Maryland, USA
Given the difficulties regarding the interpretation of common laboratory test results in polymyositis (PM) and dermatomyositis (DM) in clinical practice, we assessed their range of abnormalities, differences among phenotypes and interrelationships in a large referral population.
We retrospectively assessed 20 commonly measured blood laboratory tests in 620 well-defined PM/DM patients at different stages of illness and treatment to determine the frequency, range of abnormalities and correlations among clinical, gender, racial and age phenotypes.
Myositis patients at various stages of their disease showed frequent elevations of the serum activities of creatine kinase (51%), alanine aminotransferase (43%), aspartate aminotransferase (51%), lactate dehydrogenase (60%), aldolase (65%) and myoglobin levels (48%) as expected. Other frequent abnormalities, however, included elevated high white blood cell counts (36%), low lymphocyte counts (37%), low hematocrit levels (29%), low albumin levels (22%), high creatine kinase MB isoenzyme fractions (52%), high erythrocyte sedimentation rates (33%) and high IgM and IgG levels (16% and 18%, respectively). Many of these tests significantly differed among the clinical, gender, racial and age groups. Significant correlations were also found among a number of these laboratory tests, particularly in the serum activity levels of creatine kinase, the transaminases, lactate dehydrogenase and aldolase.
Laboratory test abnormalities are common in PM/DM. Knowledge of the range of these expected abnormalities in different myositis phenotypes, gender and age groups and their correlations should assist clinicians in better interpretation of these test results, allow for a clearer understanding what level of abnormality warrants further evaluation for liver or other diseases, and may avoid unnecessary laboratory or other testing.
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* Address correspondence to this author at the Environmental Autoimmunity
Group, National Institute of Environmental Health Sciences, National
Institutes of Health, CRC 4-2352, MSC 1301, 10 Center Drive, Bethesda,
MD 20892-1301, USA; Tel: 301-451-6273; Fax: 301-451-5585; E-mail: firstname.lastname@example.org