1 The Christ Hospital and The University of Cincinnati Medical Center, USA
2 Department of Dermatology, The University of Alabama at Birmingham, USA
Amyopathic dermatomyositis (ADM) is a rare subtype of dermatomyositis which is often recalcitrant to
immune suppressing treatments. Intravenous immunoglobulin (IVIG) has been used in the treatment of refractory
dermatomyositis. We present two patients with severe ADM, who were treated with IVIG at 2 g/kg every four weeks.
Both patients had a successful response and were able to taper the dosage of prednisone. We present both cases in
describing IVIG as a rescue and maintenance steroid-sparing agent in the treatment of severe refractory ADM. We also
review the treatment of refractory ADM with IVIg in the English literature.
Keywords: Intravenous immunoglobulin, treatment, amyopathic dermatomyositis, direct immunofluorescence.
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